27 March

3. Genes that casues severe nausea and vomiting during pregnancy has been identified

Researchers have identified two genes that are associated with severe nausea and vomiting during pregnancy, a condition known as hyperemesis gravidarum.

The cause of the condition, which is experienced by about 2% of pregnant women, has not previously been identified.

Now, a study led by researchers at UCLA has shown that the genes GDF15 and IGFBP7 are linked to hyperemesis gravidarum. These genes are involved in the development of the placenta and play key roles in appetite regulation.

The debilitating symptoms, which include dehydration, malnutrition, and rapid weight loss, can sometimes be so severe that hospitalization is required.

Previous studies have shown that severe nausea and vomiting during pregnancy tends to run in families, suggesting a genetic element to the condition.

For the current study, Fejzo and colleagues compared the DNA of pregnant women suffering from hyperemesis gravidarum with that of pregnant women who did not experience nausea and vomiting.

As reported in Nature Communications, the findings showed that DNA variation around the GDF15 and IGFBP7 genes were associated with hyperemesis gravidarum.

A separate follow-up study showed that levels of the proteins encoded for by these genes are abnormally high among women with the condition.

The next step is to find out whether it is possible to adjust the levels of GDF15 and IGFBP7 proteins safely during pregnancy to reduce nausea and vomiting.




About our blogs

We have put together weekly developments during pregnancy. These articles are only for information. Every pregnancy is different and every woman's experience may be different. We also have articles relating to women's health, infertility and plan to add information about newborn care. Through the blogs, videos and our online consultation services, we are trying to empower mothers (as well as soon-to-be-moms) with health information which is easily understandable. Our mission is to help mothers have a happy pregnancy and a very happy postpartum experience. 

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Pregnancy brings a new meaning to the concept of beauty to a woman. It is a period of immense joy, excitement and anxiety. The feeling of carrying a little soul within you is beautiful.

Last modified on Thursday, 02 August 2018 13:23
Dr Padma

Dr Padma is a Family care physician and is the Founder and CEO of MedHealthTV.


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