Now, a study led by researchers at UCLA has shown that the genes GDF15 and IGFBP7 are linked to hyperemesis gravidarum. These genes are involved in the development of the placenta and play key roles in appetite regulation.

The debilitating symptoms, which include dehydration, malnutrition, and rapid weight loss, can sometimes be so severe that hospitalization is required.

Previous studies have shown that severe nausea and vomiting during pregnancy tends to run in families, suggesting a genetic element to the condition.

For the current study, Fejzo and colleagues compared the DNA of pregnant women suffering from hyperemesis gravidarum with that of pregnant women who did not experience nausea and vomiting.

As reported in Nature Communications, the findings showed that DNA variation around the GDF15 and IGFBP7 genes were associated with hyperemesis gravidarum.

A separate follow-up study showed that levels of the proteins encoded for by these genes are abnormally high among women with the condition.

The next step is to find out whether it is possible to adjust the levels of GDF15 and IGFBP7 proteins safely during pregnancy to reduce nausea and vomiting.

https://www.eurekalert.org/pub_releases/2018-03/uoc--tgl031918.php

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